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Frankenstein’s monster with a vagus nerve stimulation device and a frog on his head
VNS

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October 28, 2025

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Frogs, Frankenstein, and VNS

The inspiration for Frankenstein is worse than fiction, but instrumental in understanding how nerves work.

A steel table, metal probes, and life-giving lightning are the images accompanying the creation of Frankenstein’s monster. Mary Shelley’s Frankenstein is a glimpse into very real scientific pursuits of the 18th century that formed the foundations of our understanding of nerves and muscle tissue, including the vagus nerve.

While 8-foot human scrapbooks weren’t plaguing Europe, scientists in the 17th and 18th centuries were experimenting with animal reanimation, using electricity. Shelley spent years studying these scientific breakthroughs and took inspiration from the findings when writing Frankenstein.

Science seems to have a fascination with frogs, and the history of understanding nerves has amphibians to thank for their role in early experimentation.

Jan Swammerdam was a 17th-century naturalist and philosopher known for creating the Bybel der Natuure (Bible of Nature) — a collection of studies on insects which, at the time, included frogs. Swammerdam’s interest in frogs had theological and scientific goals: he wanted to prove that all creatures were created by God and governed by the same biological rules. Swammerdam used similar muscle experimentation methods on frogs as those used on larger animals like cats and dogs. He exposed the leg nerves and used sharp instruments to stimulate contractions, showing a closer link between frogs and humans than was previously thought.

Luigi Galvani’s inquiry into reanimation started with a frog, a static electricity machine, and a scalpel. A frog’s leg nerves were exposed near a charged electrical machine when Galvani’s wife touched a nerve with a scalpel, causing the leg to spasm. Noting that the scalpel had been near the static electricity machine shortly before his wife had used it to touch the frog, Galvani formed and tested his theory that electrical force could travel along the nerves to the muscles, causing them to contract. He called this “animal electricity”.

Galvani also found that nerves from one frog could be attached to the muscles of another, and that the muscles from the second frog responded when the nerves were stimulated.

Shortly after Galvani published his findings, another professor of physics named Allesandro Volta disputed the notion of “animal electricity”, causing controversy in the field. By repeating Galvani’s experiments with frogs, Volta concluded that the key to nerve stimulation was in agitating them with two differing types of metal. The more dissimilar the metals, the more intense the reaction. Galvani would later disprove this by using two rods made of the same type of metal to cause muscle contractions. The result of their scholarly dispute? Both were partially right and wrong: there is no “animal electricity”, but nerve stimulation doesn’t require two differing metals to achieve.

Galvani’s nephew, Giovanni Aldini, continued his uncle’s work by publicly animating the corpses of executed criminals. Aldini inserted metal rods into the corpses and stimulated muscle movement with electricity, demonstrating a macabre display of galvanism and leading to questions about bringing back the dead.

These galvanist pursuits weren’t the only inspiration for Shelley — the author cites Erasmus Darwin (grandfather to Charles Darwin) in two editions of her work.

Erasmus Darwin was a physician, botanist, and poet, and amongst his publications on plants and evolution, he wrote on reanimation in dead microorganisms.

Arguably, the most influential figure in crafting Frankenstein was Sir Humphry Davy, a friend of Shelley’s father who allegedly inspired the character Victor Frankenstein.

Davy was a professor of chemistry at the Royal Institution in London, with crowds overfilling his lecture hall to watch his experiments. Davy used Volta’s invention—the electric pile—to investigate and prove that electricity generation depends on a chemical reaction. Shelley used some of Davy’s lectures as dialogue for Victor Frankenstein and tried to capture the professor's passion for understanding nature and his drive to master it.

Non-invasive vagus nerve stimulation (nVNS) is a form of mastery over nature. Short bursts of electrical energy are passed through the vagus nerve to relax the stress response, improve nervous system function, recalibrate certain regions in the brain, and control inflammation. What scientists learned about the effect of electrical impulses on nerves from their experiments hundreds of years ago, we use now to regulate the digestive system, improve mood, and manage chronic pain disorders via the vagus nerve.

Fortunately, nVNS can be done at home, sans steel table and metal probes.

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